If you are an AOS application and you are in a non-immigrant status (ex: F-1, O-1, TN, E-3, J-1, etc.), you can travel internationally and re-enter the U.S. in the non-immigrant status at LC stage and even after your I-140 is filed and/or approved. However, there will be international travel restrictions at the I-485 stage.

We generally advise waiting at least 60 days from your last entry into the U.S. in the non-immigrant status before filing the I-485 application. In addition, you will not be able to travel internationally from when the I-485 is filed to when the advance parole (AP) is issued, which could be several months.