Your weekly GLP-1 guide for appetite control and metabolic support.
Reconstitution (Mixing Your Vial)
Add 2.0 mL bacteriostatic water → final concentration ~5.0 mg/mL
On a U-100 insulin syringe: 1 unit ≈ 50 mcg
Use within 28 days, store in the refrigerator (2–8 °C)
Powder vial stores frozen at –20 °C
Weekly Dosing Schedule (Gradual Titration)
Inject once weekly on the same day each week. Slow escalation improves tolerability.
Weeks | Weekly Dose | Syringe Units | Volume |
Weeks 1–4 | 0.25 mg (250 mcg) | 5 units | 0.05 mL |
Weeks 5–8 | 0.5 mg (500 mcg) | 10 units | 0.10 mL |
Weeks 9–12 | 1 mg (1,000 mcg) | 20 units | 0.20 mL |
Weeks 13–16 | 1.7 mg (1,700 mcg) | 34 units | 0.34 mL |
Week 17+ | 2.4 mg (2,400 mcg) | 48 units | 0.48 mL |
*Higher doses may require multiple vials depending on supply planning.
Frequency: Once weekly, subcutaneous.
Reason for escalation: gradual titration helps reduce GI-related effects and aligns with clinical study structures.
Reconstitution Steps
Draw 2.0 mL bacteriostatic water.
Inject slowly down the vial wall.
Swirl gently (do not shake).
Label your vial with the date.
Refrigerate at 2–8 °C and use within 28 days.
Supplies Needed
Based on an 8–20 week titration plan.
Semaglutide 10mg Vials
8 weeks: 1 vial
12 weeks: 1 vial
16 weeks: 2 vials
20 weeks: 3 vials
Syringes
1 per week
8 weeks: 8 syringes
12 weeks: 12 syringes
16 weeks: 16 syringes
20 weeks: 20 syringes
Bacteriostatic Water
2 mL per vial
8 weeks: 2 mL
12 weeks: 2 mL
16 weeks: 4 mL
20 weeks: 6 mL
Alcohol Swabs
2 per week
8 weeks: 16 swabs
12 weeks: 24 swabs
16 weeks: 32 swabs
20 weeks: 40 swabs
Protocol Overview
A structured once-weekly GLP-1 regimen designed to:
Reduce appetite
Support weight management
Improve metabolic parameters
Minimize side effects through gradual titration
Storage Instructions
Lyophilized powder:
Store at –20 °C
Short-term refrigeration (2–8 °C) is acceptable
Protect from light and moisture
Reconstituted solution:
Refrigerate at 2–8 °C
Do not freeze
Use within 28 days
Allow vial to reach room temperature before opening to reduce condensation
Practical Notes
Use a new sterile insulin syringe for each injection.
Rotate injection sites (abdomen, thigh, upper arm) to prevent irritation.
Inject slowly and wait several seconds before withdrawing the needle.
If you miss a dose, take it within 5 days if possible.
Gastrointestinal symptoms early on are common; titration helps reduce them.
How It Works
Semaglutide is a GLP-1 receptor agonist that:
Reduces appetite and cravings
Slows gastric emptying
Improves glucose control
Supports meaningful weight loss (10–15% average in clinical trials)
Its long half-life (~7 days) allows convenient once-weekly dosing.
Potential Benefits
Significant weight reduction
Improved glycemic control
Appetite reduction
Cardiovascular benefits in long-term studies
Once-weekly convenience
Potential Side Effects
Common and usually mild:
Nausea
Vomiting
Diarrhea or constipation
Injection site irritation
Less common but more serious:
Pancreatitis
Gallbladder issues
Kidney concerns
Thyroid tumors observed in rodents (uncertain human relevance)
Lifestyle Support for Best Results
Prioritize adequate protein (1.2–1.6 g/kg).
Include resistance training 2–3 times weekly.
Add 150+ minutes of weekly cardio.
Maintain hydration.
Sleep 7–9 hours per night.
Track progress and consider guidance from a dietitian.
Injection Technique (Subcutaneous)
Clean vial stopper and skin with separate swabs.
Pinch skin; insert needle at 45–90 degrees.
Do not aspirate.
Inject slowly; wait 6 seconds before withdrawing.
Dispose of needles in a sharps container.
Disclaimer:
All peptide products sold on this website are for research, laboratory, and educational purposes only. They are not approved by the FDA or Health Canada, are not intended for human consumption, and should not be used for medical, cosmetic, or therapeutic purposes unless specifically prescribed by a licensed healthcare professional.
The information provided on this site is for informational and educational purposes only and does not constitute medical advice. Product descriptions, protocols, or references are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before beginning any new protocol, supplement, or treatment.
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