While donations from your Daffy account can be made only to U.S. 501(c)(3) charities, there are thousands of U.S. charities that have programs abroad or can route funds internationally.
You can give to U.S. charities with international reach: American Red Cross, Direct Relief, Doctors Without Borders, CARE, Charity: Water, GiveDirectly, International Rescue Committee, Oxfam America, Save the Children, UNICEF, World Central Kitchen, World Vision, and many more.
You can give to U.S.-based charity evaluators that recommend and facilitate global giving: GiveWell, Giving What We Can, and Innovations for Poverty Action.
You can also consider charitable intermediary organizations that may be able to forward donations to other charities around the world: Charities Aid Foundation, Give2Asia, Global Giving, Myriad USA, and more.