GLP-1 medications are not safe for everyone. You should not use a GLP-1 if you have a personal or family history of medullary thyroid carcinoma, a diagnosis of Multiple Endocrine Neoplasia type 2, a serious hypersensitivity to the medication, or are pregnant for weight-management purposes.
Absolute contraindications: Personal or family history of medullary thyroid carcinoma or MEN type 2 (boxed warning). Serious hypersensitivity to the active drug or its components. Pregnancy for weight-management indications - discontinue semaglutide at least 2 months before a planned pregnancy; stop tirzepatide or semaglutide immediately if pregnancy is recognized.
Major cautions: History of pancreatitis. Gallbladder disease risk (rapid weight loss can increase gallstone risk). Acute kidney injury risk with dehydration - push fluids and pause the medication if you have persistent vomiting or diarrhea. Diabetic retinopathy complications during rapid glucose improvement. Severe GI disease including gastroparesis. Procedures requiring general anesthesia or deep sedation (delayed gastric emptying increases aspiration risk).
Always tell your provider about all medical conditions and medications before starting treatment.