In general, MDacne products are regarded as safe for use in the last two trimesters of pregnancy as well as during breastfeeding. Topical acne treatment medications such as benzoyl peroxide and salicylic acid are absorbed into the body in very low percentages when application is minimized only to the problems areas of the face.
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That said, before using acne treatment products at any stage of pregnancy or while breastfeeding, it is highly recommended to consult with an OB/GYN first. 

For more info on acne and pregnancy, you can refer to this article in the "Acne Help" section of the MDacne website!