Generally speaking, it's not recommended to routinely regenerate your Personas. We recommend only doing so if you've dramatically shifted the types of products you're selling or who you are selling to (e.g. going from vitamins to clothing).
Persona regeneration is something our team handles on your behalf. If you'd like a refresh, reach out to your CSM and we'll walk you through the process.
For a full overview of how Personas work, including how to activate tagging and use Persona reports, see Brand Personas Reports.