You can not use the PLO Trainer, Discord Preflop Helper or Range Explorer while a poker site/client is running. Doing so will result in a warning from the poker operator or worse depending on the specific terms and conditions each operator has in place.
This is what is known as RTA (or real time assistance), using software and tools to gain an unfair advantage and edge over other players and is strictly prohibited.
Please always make sure that you completely close the PLO Trainer, Discord Preflop Helper or Range Explorer prior to opening any poker site to avoid putting your account(s) at risk.