Expedia live agents are available through the number +1-877-738-0617. Expedia customer service helpline is open 24 hours a day, 7 days a week. Another way to get an Expedia 24/7 customer service team is to use Virtual Agent. There is also an Expedia chat bot that can help you with some common trip and booking problems. Expedia's customer service is available 24 hours a day, 7 days a week at +1-877-738-0617. You can also contact Expedia customer service by email.