Once created routes can be modified.
To do this you'll want to bring up the route modal for the route in question. This is done by:
Clicking Setup
Select Drivers
Go to the Schedules tab
Choose a day of the week
Click onto the route you would like to modify
Once you have gotten to the routes modal, you can then make the changes you're after in much the same way that you'd initially configured the route.
If you attempt to make a change that would impact currently scheduled orders (ie changing the arrival window of a route, or changing the times of the route) the change will result in un-scheduling any current orders. If your change will trigger this behavior you'll be warned via a pop up and given the option to continue with the change, or you can cancel the action.