Brain Optimization and Psychedelics

Psychedelics do not unlock hidden parts of the brain, but they do temporarily increase brain network connectivity, emotional processing, and neuroplasticity. These changes can support problem solving, creativity, and the disruption of rigid thought patterns. When paired with integration and long term behavior change, these effects may contribute to lasting improvements in mental and emotional well being.

Psilocybin becomes active only after the body converts it into psilocin through dephosphorylation. Psilocin then interacts with serotonin receptors, especially 5 HT2A, which creates the characteristic effects of a psilocybin experience.

🔎 In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

🔎 The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs

🔎 Neural correlates of the psychedelic state: insights from neuroimaging studies

🔎 Psychedelics promote structural and functional neural plasticity

🔎 Restorative retelling for processing psychedelic experiences: rationale and case study