Speakers: Click on Applications
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Go to System Preferences

Select the Sound icon
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Ensure your speakers are correctly selected, and set the volume to about half.

Microphone: In System Preferences, go to the Input tab and check your correct device is selected.

Check Chrome Settings:

Click on the button with three horizontal lines to the right of your URL address bar

Select settings (This should open a new tab)

Click in the search box to the right of the “Settings” title, and type “Microphone”

Click on “Content settings” (it should have a yellow box pointing to it)

Scroll down until you see the section “Media” and select your Microphone drop-down

If there is nothing there, no Microphone is available. If you are using an external Microphone or headset, ensure it is plugged in, and restart Chrome.

If it says default, see if there is another microphone option like “internal...etc.” and try selecting that to see if it fixes the issue.

Close any background running programs like Skype that may be using your mic

Check mute switch on headset or external microphone, if using.