Runtime configuration covers settings for VSA 10 core modules:

Auto Updater keeps your VSA 10 up to date automatically. It is highly recommended that you leave this on.

VSA 10 can be optimized to perform faster or to constrain its memory consumption to a minimum.

Increasing priority to VSA 10 will ensure that VSA 10 calls will be prioritized so that the amount of time you have to wait until you receive data back is kept to a minimum.

VSA 10 User Agent is required for User Session Commands (Screen View, Webcam View, User Chat and User Support Request). 

Note: The User Agent will run on each user session on the computer. On terminal servers this can become a nuisance and can be disabled.

PowerShell User Impersonation will run PowerShell commands as the user configured. Compile the domain box only if your computer is part of a domain.