The Stamp Liquids element is a powerful new tool on the Synthace platform that simplifies and standardizes the process of transferring liquids across plates. Whether you're working with a high-throughput liquid handler or manually stamping liquids, this element helps you retain well location consistency and scale with ease.
Below are three key use cases for using Stamp Liquids in your workflows.
🔄 Using Stamp Liquids with a 96-Channel Head
If you're using an automated liquid handler with a 96-channel head (such as a Tecan Fluent, Tecan EVO or Hamilton STAR(let)), Stamp Liquids helps you transfer whole-plate layouts efficiently in a single action.
Key benefits:
Retains source well locations in the destination plates.
Supports replication: easily transfer your liquid layout to multiple destination plates.
Automatically optimizes for high-throughput devices, recognizing when to use a 96-channel head.
How it works:
Connect your source liquids (e.g., appended aliquots of compounds A and B) to the Stamp Liquids element.
Set your transfer volume and the number of plate replicates (e.g., 3).
Choose your destination plate type.
Simulate to preview the liquid handling plan—Synthace will automatically assign the 96-channel head for optimized transfers.
Execute on your device with minimal manual intervention.
This ensures fast, consistent, and layout-preserving transfers, ideal for workflows with strict well-position dependencies.
🧍♂️ Using Stamp Liquids Without a 96-Channel Head
Even if you're working with manual pipetting or devices without a 96-channel head (e.g., Integra or 8-channel pipettes), Stamp Liquids still ensures you retain well-to-well mapping.
Key benefits:
Enables consistent layout stamping even during manual execution.
Works with any pipetting approach, including manual or semi-automated systems.
Guarantees destination wells match the original layout for traceability.
How it works:
Set up your source liquids and connect to the Stamp Liquids element.
Define the number of replicates and destination plate type.
Simulate and review the layout in preview mode.
Execute manually or on your non-96-channel device, following the clear location-preserving instructions.
Whether you're scaling down your automation or running small-scale experiments, this maintains reproducibility and accuracy.
💧 Creating Multiple Plates Using the Stamp Liquids Element with a Dispenser
The Stamp Liquids element in Synthace provides one of the simplest and most efficient ways to generate multiple plates from a single source plate—especially when paired with a dispenser like a Labcyte Echo.
This guide walks you through the key functionality and benefits of using this workflow.
🔑 Key Functionality
1. Use of the Stamp Liquids Element
The Stamp Liquids element allows you to rapidly stamp (or replicate) a predefined set of liquids from a single source plate into multiple output plates.
2. Dispenser Integration
The workflow is designed to run on acoustic dispensers such as the Labcyte Echo, ensuring precise and high-throughput liquid transfers.
3. Single Source, Multiple Outputs
You can create multiple identical output plates (e.g., 18 or more) using one source plate containing all your compounds—ideal for screening or replicating conditions.
4. Predefined Compounds in the Table Editor
Liquids are defined and organized using the Table Editor. For example, a 384-well source plate can be loaded with your full set of compounds, ready for stamping.
5. Streamlined Workflow and Simulation
The simulation preview clearly shows your source and output plates. Once connected, each compound will be consistently placed in the same location across all output plates.
✅ Key Benefits
Efficiency: Stamp dozens of plates in a fraction of the time with minimal setup.
Simplicity: The workflow is straightforward and accessible, even for new users.
Scalability: Easily scale up plate numbers without additional complexity.
⚙️ Advanced: Creating Autoscaling Workflows with Stamp Liquids + Calculate Value
Power users can combine Stamp Liquids with the Calculate Value element to create autoscaling workflows that adapt based on experimental needs.
Use case example:
You’ve created three plates of compounds (A and B) and now want to stamp a set of cultured cell lines (e.g., Cell Type 1, 2, 3) onto those compound plates.
Workflow steps:
Use Stamp Liquids to generate your compound layout across multiple plates.
Use a second Stamp Liquids element to stamp your cell lines onto the compound plates.
To dynamically scale this stamping based on the number of compound plates, connect a Calculate Value element.
Use the Output Liquid Count from the compound stamping as input.
Define a formula in Calculate Value to control the number of replicates in the second Stamp Liquids element.
This automatically adjusts how many times your cell lines are stamped.
This technique is ideal for scaling up experiments or adapting workflows on the fly without manual recalculation, improving automation and flexibility.
💡 Summary
The Stamp Liquids element allows you to:
Preserve well positions across plates.
Use 96-channel heads for high-throughput workflows.
Stamp onto pre-filled plates (e.g., cell lines + compounds).
Automate scaling logic with the Calculate Value element.
This functionality is especially valuable for screening, dose-response setups, or any process where well identity and layout integrity are essential.