Melanotan I is a synthetic peptide that mimics the natural hormone alpha-melanocyte-stimulating hormone (α-MSH), which signals the skin to produce melanin.

In research settings, it has been studied for increasing skin pigmentation and improving tolerance to UV exposure, particularly in photosensitivity disorders.

• Add 5.0 mL bacteriostatic water → final concentration 2.0 mg/mL

• This dilution makes microgram dosing easier and more accurate

• 0.25 mg – 1.0 mg daily

• Gradual escalation is commonly used:

• 0.25 mg → 0.50 mg → 1.0 mg

• Most adults do not exceed 1 mg per day

Starting low allows the body to adjust and may reduce early side effects such as nausea or flushing.

• At 2.0 mg/mL → 1 unit = 0.01 mL ≈ 20 mcg on a U-100 insulin syringe

Lyophilized (freeze-dried):

• Store frozen at −20 °C (−4 °F)

Reconstituted:

• Refrigerate at 2–8 °C (35.6–46.4 °F)
• Use within 2–4 weeks

*Split doses may be used if preferred.

Frequency: Once daily, subcutaneous

Reason for escalation: Gradual titration may improve tolerability and allows the body to adjust to melanocortin receptor activation.

Draw 5.0 mL bacteriostatic water

Inject slowly down the vial wall (prevents foaming)

Gently swirl or roll — never shake

Label vial with reconstitution date

Refrigerate at 2–8 °C

This creates a 2.0 mg/mL concentration, which allows convenient measurement of microgram doses using a standard insulin syringe.

• 8-week protocol: ~4 vials
• 12-week protocol: ~5 vials
• 16-week protocol: ~7 vials

• 1 per day

• 8 weeks: 56
• 12 weeks: 84
• 16 weeks: 112

• 8 weeks: 20 mL
• 12 weeks: 25 mL
• 16 weeks: 35 mL

• 2 per day

• 8 weeks: 112
• 12 weeks: 168
• 16 weeks: 224

Goal:

Gradually increase melanin production and skin pigmentation through melanocortin receptor activation.

Structure:

• Once-daily injections

• Gradual escalation → 0.25 mg → 0.50 mg → 1.0 mg

• Pigmentation typically develops over several days to weeks

Reconstitution:

5.0 mL → 2.0 mg/mL

Storage:

Freeze lyophilized; refrigerate after mixing.

Lyophilized:

• Store frozen at −20 °C

• Protect from light and moisture

Reconstituted:

• Refrigerate at 2–8 °C

• Use within 2–4 weeks

Handling Tips:

• Allow frozen vial to reach room temperature before opening
• Avoid heat or direct sunlight
• Avoid repeated freeze–thaw cycles

• Start low (0.25 mg) to reduce nausea or flushing
• Increase slowly over the first week
• Use a new sterile syringe each injection
• Rotate injection sites (abdomen, thighs, upper arms)
• Stay consistent with daily timing

Melanotan I activates the MC1R melanocortin receptor in melanocytes.

This stimulates:

• Melanin production

• Gradual skin pigmentation

• Increased UV tolerance

The peptide essentially signals the skin to produce more of its own protective pigment.

• Gradual increase in skin pigmentation

• May improve sun tolerance

• Studied for photosensitivity disorders

• More selective melanocortin activity than related peptides

• Mild nausea or flushing

• Freckle darkening or increased pigmentation

• Mild injection-site irritation

• Occasional fatigue or headache

Starting at lower doses often reduces early side effects.

• Moderate sun exposure helps stimulate melanin production
• Stay well hydrated
• Maintain consistent dosing schedule
• Use sun protection as needed while pigmentation develops

Before injecting:

• Wash hands
• Clean vial stopper
• Clean injection site
• Draw dose and remove air bubbles

How to inject:

Pinch skin
Insert needle at 90° (or 45° if lean)
Inject slowly
Remove needle straight out
Dispose in sharps container

After:

• Refrigerate vial
• Rotate injection sites
• Monitor for redness or irritation

Disclaimer:

All peptide products sold on this website are for research, laboratory, and educational purposes only. They are not approved by the FDA or Health Canada, are not intended for human consumption, and should not be used for medical, cosmetic, or therapeutic purposes unless specifically prescribed by a licensed healthcare professional.

The information provided on this site is for informational and educational purposes only and does not constitute medical advice. Product descriptions, protocols, or references are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before beginning any new protocol, supplement, or treatment.

By purchasing from this website, you acknowledge and agree to use these products responsibly and in accordance with all applicable laws and guidelines.