Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans
This study found that repeat doses of IV NAD+ increased NAD+ metabolite levels, reduced oxidative stress, and boosted the expression of genes linked to longevity without major adverse effects. The study focused on healthy elderly individuals and demonstrated that NAD+ could slow down age-related decline (Braidy, 2018).
A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+
This pilot study documented how NAD+ and its metabolites change during and after a 6-hour IV infusion of NAD+. The study revealed that NAD+ was rapidly removed from the plasma for the first 2 hours and later metabolized. Urinary excretion of NAD+ and methyl nicotinamide was observed, with no significant plasma rise until after 2 hours (Grant et al., 2019).
Key Note: This is why Dripdok ensures proper drip rate by body weight, age and other metabolic factors to ensure complete intracellular uptake. Low doses, fast pushes result in rapid metabolism of NAD+ to AMP rather than improving mitochondrial health, DNA repair and more.
The web is full of misinformation geared at marketing something that simply isn't correct. Dripdok's MDs and PhD's keep their finger on the pulse of human studies around NAD and is realistic with their advice. Don't be fooled - NAD+ has incredibly poor intracellular uptake and improper drip rates and dosages without proper insight is simply wasting your money.
We use NON-https://intercom.help/dripdok/en/articles/9549971-explanation-of-nad-dosages-and-administration bio-fermented USP - IV grade NAD that has incredible potency, has been produced within days of your injection and we utilize a highly proprietary and patented method to take intracellular uptake from 10-20% to 40-60%.
We were the first in SEA and we continue to improve through data and quality control and outcome assessment.
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
This paper conducted a systematic review of the effects of NAD+ precursors, including IV administration, in age-related degenerative diseases. It found that NAD+ levels decline with age, and boosting NAD+ can potentially improve health outcomes in degenerative conditions. However, the long-term effects of raising NAD+ levels in humans remain under investigation (Braidy & Liu, 2020).
NAD+ Therapy & Advanced Longevity ProtocolsPatients who undergo monthly 250mg NAD+ infusions post-protocols, combined with daily use of our ultra-high absorption NMN or Tri-Revive Sublingual Powder, have experienced extraordinary results. Our data, collected from over 50 patients, shows an average reduction in DNA methylation age by 15 years over the course of 1.5 years.
Cardiovascular Benefits:
These protocols have also led to substantial improvements in cardiovascular health, with patients significantly increasing their Heart Rate Variability (HRV)—a key marker of heart health and longevity. Patients who have been with us for over 3 years have shown continued improvement, reinforcing that NAD+ therapy is a long game with profound, sustained benefits.
Rapid Performance Enhancements:
For those looking for more immediate gains, cyclic use of Methylene Blue in combination with NAD+ has been a game changer. In less than 14 days, we’ve seen dramatic improvements in HRV and VO2 max—the body’s ability to efficiently use oxygen. This is a powerful performance booster and recovery enhancer.
These findings are based on real data from Oura Rings tracking HRV and fitness levels, with the results validated in ongoing studies of long-term patients.
If you’re interested in a personalized protocol that can help you optimize your biological age and cardiovascular health, let us know!
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
This review highlights how IV NAD+ can act as a signaling molecule to regulate metabolic and cellular processes. It points out that NAD+ supplementation has shown promise in extending the lifespan of animals and potentially enhancing human healthspan through mechanisms like DNA repair and immune function (Rajman et al., 2018).
These papers collectively suggest that intravenous NAD+ administration in humans can increase NAD+ levels, reduce oxidative stress, and potentially benefit aging-related conditions, though more research is needed to determine its long-term safety and effectiveness.