For an evidence-based cognitive boosting peptide protocol, combining several peptides with known benefits for brain function, memory, focus, and neuroprotection can create a comprehensive approach. The peptides recommended in this protocol have been supported by scientific research for enhancing cognitive performance and protecting the brain.
Cognitive Boosting Peptide Protocol
Semax:
Mechanism: Semax is a synthetic neuroactive peptide derived from adrenocorticotropic hormone (ACTH), shown to improve memory, enhance focus, and protect neurons from oxidative stress. It stimulates BDNF (brain-derived neurotrophic factor), supporting neurogenesis and cognitive function.
Dosage: 300 mcg intranasally, 2-3 times daily.
Duration: 4-8 weeks for cognitive enhancement【36†source】【37†source】【41†source】.
Selank:
Mechanism: Another neuropeptide that stabilizes mood, reduces anxiety, and enhances cognitive abilities by modulating the neurotransmitter systems (especially GABA and serotonin). It also improves memory and learning capacity.
Dosage: 300 mcg intranasally, 2-3 times daily.
Duration: 4-8 weeks.
Stacking: Can be combined with Semax for synergistic effects on cognition and mood【36†source】【39†source】.
Cerebrolysin:
Mechanism: A powerful neuropeptide mixture that promotes neuroplasticity, neuroprotection, and cognitive enhancement by mimicking nerve growth factor effects. It is often used in clinical settings for cognitive decline, brain injury, and neurodegenerative conditions.
Dosage: 5-10 mL intramuscular (IM) or intravenous (IV), 5 times per week.
Duration: 4-6 weeks.
Benefits: Improves memory, learning, and focus, particularly useful for neuroprotection and age-related cognitive decline【36†source】【38†source】.
NAD+ (Nicotinamide Adenine Dinucleotide):
Mechanism: Although not a peptide, NAD+ is critical for cellular energy production, mitochondrial function, and cognitive health. It supports neuronal repair and has been studied for improving cognitive performance in neurodegenerative conditions.
Dosage: 500-1,000 mg IV for 4-5 consecutive days, followed by maintenance doses weekly or as needed.
Benefits: Supports mitochondrial function and cognitive longevity, particularly for individuals experiencing cognitive decline or brain fog【30†source】【37†source】【38†source】.
Dihexa:
Mechanism: Dihexa is a synthetic small peptide shown to enhance synaptic connectivity and promote learning and memory. It acts on hepatocyte growth factor (HGF), which plays a role in synaptic plasticity and neuroprotection.
Dosage: 20-40 mg orally or 1-2 mg topically daily.
Duration: 8-12 weeks.
Benefits: Ideal for boosting learning, memory, and synaptic health【41†source】【35†source】.
Epitalon:
Mechanism: A telomerase-activating peptide that promotes longevity by protecting telomere length, thus potentially supporting cognitive longevity and neuroprotection.
Dosage: 5-10 mg subcutaneously (SubQ) daily for 10-20 days.
Frequency: 2-3 times per year for maintenance of cognitive health.
Benefits: Improved neuroplasticity and longevity of cognitive functions【36†source】【37†source】.
Additional Recommendations:
Dietary Support: Focus on a diet rich in omega-3 fatty acids, antioxidants, and B-vitamins to support brain health. Consider adding NAD+ precursors like NMN or NR to support mitochondrial health【39†source】.
Lifestyle: Regular physical exercise, adequate sleep, and mindfulness practices such as meditation can synergize with peptide therapies to further enhance cognitive function【37†source】.
This peptide protocol combines neuroprotection, memory enhancement, and long-term cognitive support. It is especially suited for individuals seeking to improve focus, learning, and cognitive resilience against aging or neurodegenerative conditions.