Testosterone Replacement Therapy (TRT) is a medical treatment used to restore healthy testosterone levels in men who have been clinically diagnosed with low testosterone (also known as hypogonadism).
TRT is intended for men who experience ongoing symptoms related to low testosterone and have blood test results confirming deficiency.
What is Testosterone?
Testosterone is the primary male sex hormone responsible for:
Sex drive (libido)
Erectile function
Muscle mass and strength
Bone density
Mood regulation
Energy and motivation
Red blood cell production
Mental clarity and cognitive function
Testosterone levels naturally decline with age, starting around age 30, but some men experience a more significant drop leading to symptoms that affect daily life and long-term health.
Symptoms of Low Testosterone
Common symptoms include:
Low energy or chronic fatigue
Reduced libido or erectile issues
Loss of muscle mass or strength
Difficulty losing fat
Depressed mood or irritability
Poor concentration or memory
Lack of motivation
Poor sleep
Reduced sense of well-being
If these symptoms persist and are confirmed by a blood test showing suboptimal testosterone levels, TRT may be appropriate.
Why TRT Is Prescribed
TRT is prescribed to restore testosterone to healthy physiological levels—within the upper half of the reference range—aiming to eliminate symptoms and improve overall physical, mental, and sexual health.
TRT is not about “high” testosterone. The goal is symptom resolution with the lowest effective dose to maintain healthy levels and minimise side effects.
Forms of Testosterone Treatment
Our doctors prescribe testosterone in the following forms:
Injections (most common and effective)
Usually administered intramuscularly (into the muscle) 2–3x per week for stable levels
Transdermal (cream or gel)
Used for men with needle phobia or special circumstances
The most suitable option depends on your preference, lifestyle, and medical history. Your doctor will guide you based on clinical need.
Supporting Medications
In some cases, doctors may prescribe additional medications to:
Manage side effects (e.g., estrogen-related symptoms)
Preserve fertility (if actively trying to conceive)
Optimize outcomes (e.g., adjust estradiol or DHT balance)
These are only used if clinically indicated and are prescribed based on follow-up blood work and symptom reviews.
What to Expect on Treatment
Weeks 1–4: Subtle improvements in energy, sleep, and mood
Weeks 4–6: Libido may increase; muscle strength may begin improving
Weeks 6–8: Most patients report improved energy, sex drive, and mental sharpness
Week 8: First follow-up blood test to assess testosterone and estradiol levels
Weeks 8–16: Continued improvements in body composition, mood, and recovery
Weeks 16–26+: Stabilisation and long-term symptom resolution
Improvement is gradual and accumulates over time, especially when combined with lifestyle changes (e.g., nutrition, training, sleep).
Who Is Not a Candidate?
TRT is not prescribed if:
Blood tests are in the normal range
Symptoms are due to other causes (e.g., depression, poor sleep, high stress)
There are contraindications such as prostate cancer or untreated sleep apnea
You’re trying to conceive in the next 6–12 months (unless fertility medications are added)
Your doctor will determine eligibility based on clinical history, symptom profile, and pathology.
Is TRT Safe Long Term?
When medically supervised with regular blood testing, TRT is considered safe and effective. Your doctor will monitor key markers such as:
Testosterone (total & free)
Estradiol
Hematocrit & hemoglobin
Lipids
Liver function
PSA (prostate-specific antigen)
Follow-up testing ensures any risks are mitigated and dosages remain optimal.
Next Steps
If you're experiencing symptoms of low testosterone:
Create a Hormn account
Get started with Low Testosterone treatment
Order your blood tests
Complete your health questionnaire
Book a doctor consultation once results are in
If eligible, treatment can be prescribed and delivered quickly. Regular support and follow-up are included in your subscription.