⚠️ Heads up: Belle's compounded GLP-1 formulations with added B vitamins are being phased out. New semaglutide orders no longer include B12 (VitalRx is discontinued), but tirzepatide with B6 is still shipping from BPI / Pharmacy Hub for the next few months. This article explains what to expect if your vial contains a B vitamin. For new semaglutide orders, see Understanding Your Semaglutide Shipment.
Some Belle patients have GLP-1 vials that include added B vitamins. Tirzepatide is compounded with vitamin B6 through BPI / Pharmacy Hub, and semaglutide was compounded with vitamin B12 (methylcobalamin) through VitalRx. These vitamins are commonly used in compounded formulations and do not change the safety, effectiveness, or intended use of your medication.
Belle is transitioning to formulations without added B vitamins:
Semaglutide + B12 (VitalRx): Already phased out as of mid-April 2026. New semaglutide orders ship from Hallandale, Boudreaux, or VialsRx and do not contain B12.
Tirzepatide + B6 (BPI / Pharmacy Hub): Still active. Phasing out over the next few months. New tirzepatide orders may still include B6 in the meantime.
Patients with a B vitamin allergy or sensitivity can request our additive-free formulation. See Can I get compounded GLP-1 without B vitamins or other additives? for details.
What the Added Vitamins Do
Tirzepatide + B6: Vitamin B6 supports protein metabolism, mood regulation, immune function, and may help reduce nausea. The solution appears clear or slightly yellow.
Semaglutide + B12: Vitamin B12 supports red blood cell formation, nerve function, and energy. The solution appears pink or red due to the color of B12.
Good to know: Both medications use only the base form of the active ingredient (not salt forms) and are produced by FDA-registered compounding pharmacies.
Reading Your Vial Label
If your vial is compounded with a vitamin, the label lists two active ingredients. Here's how to read it:
Tirzepatide + B6 (Pyridoxine HCl):
The label shows two separate lines: the tirzepatide content and the B6 content. Example: "60 mg/3 mL (20 mg/mL)" is the tirzepatide, "30 mg/3 mL (10 mg/mL)" is the B6. Use the tirzepatide line for dosing.
Concentration | Vial Size | Total Tirzepatide | Total B6 |
10 mg/mL | 1 mL | 10 mg | 10 mg |
10 mg/mL | 3 mL | 30 mg | 30 mg |
20 mg/mL | 2 mL | 40 mg | 20 mg |
20 mg/mL | 3 mL | 60 mg | 30 mg |
Semaglutide + B12 (Methylcobalamin):
The label shows a combined notation. Example: "2.5/0.5/mg/mL (10mg/2mg/4mL)" means 2.5 mg semaglutide plus 0.5 mg B12 per mL. Use the first number for dosing.
Concentration | Vial Size | Total Semaglutide | Total B12 |
1 mg/mL | 1 mL | 1 mg | 0.5 mg |
2.5 mg/mL | 1 mL | 2.5 mg | 0.5 mg |
2.5 mg/mL | 2 mL | 5 mg | 1 mg |
2.5 mg/mL | 3 mL | 7.5 mg | 1.5 mg |
2.5 mg/mL | 4 mL | 10 mg | 2 mg |
For both medications, only the first number matters for dosing. The vitamin content does not change your injection volume. If you're unsure how many units to draw, see How do I convert units to milligrams for my dose? or use the Dosage Calculator.