GLP-1 medications like semaglutide and tirzepatide mimic a natural gut hormone called glucagon-like peptide-1. This hormone helps regulate appetite, digestion, and blood sugar. When combined with healthy nutrition, movement, and support, GLP-1 treatments can help many people achieve sustainable weight loss and improve metabolic health.
How they work: GLP-1 medications act on your stomach (slowing emptying so you feel full longer), your brain (reducing cravings and making it easier to eat smaller portions), and your pancreas and liver (improving blood sugar control). Most are given as once-weekly injections.
Potential benefits: Weight loss through reduced appetite and better portion control. Metabolic improvements including better A1c, cholesterol, and blood pressure for many patients. Behavioral momentum - making it easier to stick to nutrition and movement routines.
Who they're for: Adults with obesity, overweight adults with a weight-related condition, and many people with type 2 diabetes.
Who they're not for: People with a personal or family history of medullary thyroid carcinoma (MTC) or MEN type 2, those who are pregnant or breastfeeding, or anyone with a known allergy to the medication. Your provider screens for these during your assessment.