Each drug combination in the drug interaction checker is assigned one of the following 5 classification levels, which were extrapolated from existing human drug interaction checkers.
Contraindicated
Data demonstrate that the compared drugs are likely to interact with each other and present a significant clinical concern. Use together is contraindicated; alternate therapies should be considered. In cases of absolute clinical necessity, use of this drug combination should only be undertaken when no other options exist and with clear, unmistakable communication between all medical personnel and pet owners about risks and what adverse effects warrant immediate action.
Use with Caution, Major
Data demonstrate that the compared drugs may interact with each other and present a significant clinical concern. Concurrent use should be avoided if possible; alternate therapies should be considered. If concurrent use cannot be avoided, patients should be assessed to determine if the benefits of this drug combination outweigh the risks. Patients should be closely monitored to minimize any potential adverse effects anticipated with this drug combination; dose adjustments of either drug may be required.
Use with Caution, Moderate
Data demonstrate that the compared drugs may interact with each other and present a significant clinical concern. Patients should be assessed to determine if the benefits of this drug combination outweigh the risks. Patients should be closely monitored for development of adverse effects; dose adjustments of either drug or use of alternative therapies may be necessary.
Use with Caution, Minor
Data demonstrate that the compared drugs may interact with each other and present a clinical concern. The benefits of this drug combination often outweigh the risks. Patients should be monitored for the presence of adverse effects; dose adjustments of either drug may be necessary.
No known interaction
Data demonstrate that these drugs do not interact.
No data
Either this drug combination has not been evaluated yet for inclusion in this tool or no data is available for this drug combination. Please refer to the Drug Interactions section of each drug monograph; use clinical judgment when prescribing these drugs together.