Create from Specification Text

Locate the text in your specification that labels and describes your Markush group.
Select the label and description text.
Press Ctrl+Shift+R (Cmd-Shift-R for Macs)

OR

Select the Convert to R-Group option from the Terms menu

OR

Right-click the selected text and select Convert to R-Group from the context menu provided.

Create in the R-groups Manager

Open the R-groups Manager.
Click the +Add button or the Add New R-group option under the R-groups menu.
Enter your group name.

Note that your group name can nest other R-groups (e.g., "R2 and R3"). Existing R-groups nested this way will be individually tagged and will reflect name updates wherever used.

Ctrl+Shift+= turns superscript style on/off. Ctrl+= toggles subscript style. Sub/superscript styles can also be applied to selected characters using toolbar or popup controls where provided.
Click the Save button.
Add descriptions for your R-groups.