This might be the first time you are using Synthace, or maybe you want a refresher on how to express your scientific protocols in Synthace. This is done in the Workflow Builder, where you can use and wire together building blocks, called elements, to describe your scientific protocol.

The Core Elements are the base level building blocks that you can use to flexibly describe your protocol. They consist of common actions you will recognise from the lab such as:

The Core elements can be added to your workflow canvas, wired together to describe the flow of reagents or samples through your protocol, so that you achieve the science that you want to carry out in the lab.

To learn in more detail about each of the Core Elements and how to build workflows more generally, hop on over here. Subsequent tutorials of how to build DOE workflows will not go into the same depth as in the Core Elements tutorials, so if you are new to Synthace or the Core Elements, that is a great place to start.

Not all of the Core Elements can have DOE applied to them, but the most important ones are built to support DOE. How do I know which elements I can apply DOE to? We have made that easy for you by adding a DOE icon to the element cards on the canvas.

Synthace supports liquid mixture DOEs, which comes in handy if, for example, you want to optimise the components that make up a culture medium or buffer, or the excipients in a drug substance formulation. As such there are two Core Elements that support DOE:

Both elements provide a way to describe how you want a set of mixtures to be made, either by mixing a set of liquids at specific compositions to an empty well - Make Mixtures, or onto liquids that are already in a well - Mix Onto.