Elevated estradiol (a form of estrogen) is a potential side effect of fertility treatment, especially when stimulating LH and FSH pathways. While some increase is expected, high estradiol can lead to unwanted symptoms like mood swings, nipple sensitivity, or water retention.
Why It Happens
Fertility medications can stimulate the testes and overall hormone production, which may cause a rise in estradiol. This is often temporary but may require intervention.
How We Manage It
1. Smaller, More Frequent Injections
Frequent lower-dose injections help reduce hormonal spikes and keep estrogen levels more stable.
2. Aromatase Inhibitor (If Needed)
If bloodwork shows estradiol remains high and symptoms are present, your doctor may prescribe an aromatase inhibitor to reduce estrogen conversion. This is only used when clinically necessary.
Addressing Root Causes
These factors can contribute to elevated estradiol and should be addressed alongside medical treatment:
Excess Body Fat (over ~16%): Adipose tissue converts testosterone to estrogen.
Undiagnosed Sleep Apnea: Can affect hormone metabolism.
Insulin Resistance: Common in those with poor metabolic health.
Alcohol Use: Especially beer and spirits—limit or avoid.
Liver Function: Liver helps clear excess estrogen; poor function can cause buildup.
Lack of Cardio Exercise: Cardiovascular activity helps regulate estrogen metabolism.
What to Do
Follow your prescribed injection schedule carefully
Prioritise fat loss if body fat is elevated
Limit alcohol and processed carbs
Include cardio (20–30 mins, 5-7x per week)
Speak with your doctor if symptoms persist
Elevated estradiol can happen with fertility treatment but is manageable. Small, frequent doses help prevent sharp hormone spikes. Lifestyle changes and, in some cases, medication may be used to correct levels.
Monitor symptoms and bloodwork closely, and contact your doctor if you have concerns.