The error message (An Error Occurred when trying to Create Shipment: There was no endpoint listening at http://##.###.###.###/ClientServer/ClientShipService.asmx that could accept the message. This is often caused by an incorrect address or SOAP action. See InnerException, if present, for more details.) from GFS can be caused by the following reasons:
If you connect to GFS via a local installation, then it suggests that PC could be switched off or has no internet connection, Or if you connect via Rackspace, then GFS would need to be informed to investigate the outage.
Your networks security system is blocking communication between our IPs and the host. If this is the case, then please raise a new case online and reference the title of this article.