Some patients experience acid reflux, indigestion, or a burning sensation in the chest or throat while using GLP-1 medications. These symptoms are typically mild and temporary, often related to the way GLP-1s slow down stomach emptying.
What Causes It
Delayed gastric emptying: Food stays in the stomach longer, increasing pressure and acid build-up.
Larger or fatty meals: These are harder to digest and more likely to cause reflux when stomach movement is slowed.
Lying down soon after eating: Can make reflux more likely.
What You Can Do
Eat smaller meals: Have 3–4 smaller meals or snacks throughout the day rather than large meals.
Avoid trigger foods: Common culprits include fatty foods, spicy meals, chocolate, caffeine, and alcohol.
Avoid eating close to bedtime: Finish eating at least 2–3 hours before lying down.
Elevate your head while sleeping: A slight incline helps reduce night-time reflux.
Chew slowly and eat mindfully: Rushed eating can increase stomach pressure.
When to See a Doctor
Reflux symptoms persist beyond 2–3 weeks
You experience frequent night-time heartburn
You have difficulty swallowing or notice weight loss due to reduced intake
You need to take antacids frequently to manage symptoms
Acid reflux can be common with GLP-1s, especially at higher doses, but usually improves over time. Your doctor can help adjust your plan or recommend temporary treatment if needed.