GLP-1 medications slow digestion and affect the hunger centers in your brain. While these effects help with weight loss, they can also cause nausea—especially early in treatment or after a dose increase.
What to Expect
Mild to moderate nausea is common in the first 1–3 weeks of starting or increasing your dose.
Some patients may also feel bloated or full very quickly after eating.
Vomiting is less common, but can occur if the dose is too high or if eating habits don’t adjust.
Why It Happens
GLP-1 medications slow how quickly your stomach empties. If you eat too much, too fast, or high-fat foods, your stomach may struggle to process it, leading to nausea. The effect is more noticeable at higher doses.
How to Minimise It
Eat small meals: Stick to small portions, especially at dinner.
Eat slowly: Chew thoroughly and avoid rushing.
Avoid high-fat meals: Fat slows digestion further and can worsen symptoms.
Stay upright after eating: Don’t lie down for 1–2 hours post-meal.
Limit alcohol: It can irritate the stomach and increase nausea.
Hydrate slowly: Sip water throughout the day, not all at once.
When to Contact Your Doctor
Persistent nausea or vomiting beyond the first 2–3 weeks.
Inability to eat or drink without vomiting.
Signs of dehydration (dry mouth, dizziness, dark urine).
Vomiting blood or material that looks like coffee grounds—seek urgent care.
Mild nausea is expected and usually improves with time. In most cases, slowing your eating and adjusting food choices is enough to manage it. If not, we can adjust your dose or explore support options.