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Understanding Common Side Effects of GLP-1/GIP Medications

And how we support you every step of the way

Updated over a week ago

GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) medications are powerful tools for managing weight and blood sugar. While these medications are highly effective, they can sometimes cause side effects—especially when you’re just getting started.

At Fridays, your health and comfort are our top priorities. That’s why we offer unlimited provider visits and can prescribe anti-nausea medications like Zofran (ondansetron) to help manage any discomfort you may experience.


Most Common Side Effects

Here are some side effects patients may experience with GLP-1/GIP medications:

1. Nausea

This is the most frequently reported side effect, especially in the first few weeks. It's usually mild and often improves over time as your body adjusts.

We can help: If nausea becomes bothersome, our providers can prescribe Zofran (ondansetron), a safe and effective medication to help you feel better quickly.


2. Vomiting

Less common than nausea, vomiting can occur—particularly with rapid dose increases. Staying hydrated and eating smaller, bland meals may help.


3. Constipation

Changes in digestion are common. Drinking plenty of fluids, eating fiber-rich foods, and regular movement can help relieve symptoms.


4. Diarrhea

Some patients may experience the opposite effect—looser or more frequent stools. This typically resolves as your body adapts.


5. Bloating and Gas

Mild bloating or gas is not unusual, especially early on. These symptoms are typically temporary.


6. Decreased Appetite

GLP-1/GIP medications are designed to reduce hunger. While this is a desired effect, it’s important to maintain a balanced diet with essential nutrients.


You’re Not Alone—We’re Here to Help

Every body responds differently. That’s why we provide:

Unlimited provider visits — Chat with a licensed provider anytime you need help or have questions.

Supportive care — From adjusting your dose to prescribing medications like Zofran, our clinical team is here for you.

Personalized guidance — We’ll help you manage side effects so you can stay on track and feel your best.


Questions or concerns?

Reach out anytime via your patient portal or schedule a provider visit at your convenience. We’re with you every step of the way.

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