YES, but you need to keep in mind the audience size!
In fact, we strongly recommend that you work with audience sizes that are big enough. This requirement already excludes all small towns and cities that do not have enough people.
For example:
For the Spanish city of Denia, the audience size is quite small.  | But for the French city of Reims, the size of the audience is good enough.  |
But let's say you want to know who are the people interested in Champagne geolocated in the city of Reims, which is the undisputed reference in terms of the birthplace of this sparkling wine. Well, the size of the audience decreases and becomes impossible to profile.
| As you can see, by adding only one interest, the audience size drops by more than half.  |
To keep in mind
👉 When you want to base your profiling on a city, make sure you choose a city with a large enough population so that when you add interest or behavioral criteria.