While uncommon, GLP-1 medications may increase the risk of pancreatitis (inflammation of the pancreas) and gallbladder issues such as gallstones. These side effects are considered rare but serious, and it’s important to recognise the signs early.
Pancreatitis – What to Watch For
Pancreatitis can happen in some people using GLP-1 medications. Although the overall risk is low, seek urgent medical attention if you experience:
Severe, persistent upper abdominal pain, especially after eating
Pain that radiates to the back
Nausea and vomiting that doesn’t improve
Fever or elevated heart rate
If pancreatitis is suspected, stop your medication immediately and speak to your doctor or go to the hospital. Do not restart unless your doctor advises it's safe.
Gallbladder Symptoms – What to Watch For
GLP-1s can also increase the chance of gallstones, especially with rapid weight loss. Warning signs include:
Sudden, sharp pain in the right upper abdomen (may come and go)
Pain after eating fatty meals
Nausea, vomiting, or bloating
Yellowing of the skin or eyes (jaundice)
These could indicate gallstones or gallbladder inflammation. See your doctor if these symptoms occur.
Who Is at Higher Risk?
History of gallstones or pancreatitis
Rapid weight loss
High-fat diets
Women, especially over age 40
If you have any of these risk factors, let your prescribing doctor know before or during treatment.
These side effects are rare, but serious symptoms should never be ignored. If you experience any of the signs listed above, stop treatment and seek medical care immediately.
Our doctors screen for these risks during your initial consultation, but monitoring your symptoms is key to safe treatment.