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Proofig – Frequently Asked Questions

Proofig – Frequently Asked Questions

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Written by Dekel Faruhi

1. About Proofig

What drove you to establish Proofig?

As an experienced scientific researcher for over two decades, Dr. Dror-Kolodkin-Gal has witnessed the impact of inadvertent image errors in publications – errors that have a toll upon researchers, their research institutes, and the publishers themselves. Looking for a solution, Dror and his co-founders founded Proofig to prevent these events.
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Where does Proofig stand in the field of image verification?

Proofig is at the forefront of scientific image verification, collaborating with world-leading publishers, journals, and research institutions. Our innovative AI-powered platform offers unique capabilities in detecting various forms of image manipulation, including AI-generated images. Proofig's wide adoption by major publishers and universities, coupled with recognition from leading research integrity officers, underscores our position as a trusted leader in maintaining scientific image integrity.


2. Proofig's Capabilities

What kind of manipulations can Proofig detect?

Proofig's AI system detects a wide range of image issues, including:

Our technology works across various image types, including microscopy, Western blots, and FACS images. Proofig AI also analyzes graphs, charts, diagrams, and plots. Proofig's comprehensive analysis compares images within the manuscript, against each other, and with a PubMed-derived database of more than 155 million images from published literature. For Western blots, Proofig AI can display a heatmap overlay that highlights the portion of the image suspected of manipulation.
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What type of scientific images is Proofig intended for?

Proofig uses an advanced AI system and image processing, capable of analyzing a wide variety of images, including:

  • All types of microscopies (confocal, light or electron)

  • Western blot

  • FACS

  • In-vivo and in-vitro images

  • Plants, plates, and more

  • Graphs, charts, diagrams, and plots

Can Proofig detect image manipulations in non-life science fields, such as physics or materials science?

While currently focused on life sciences, Proofig's technology is rapidly advancing. We can analyze any captured (not computer-generated) scientific images. If your field uses such images, we're eager to explore solutions. Contact us to discuss your specific needs. In addition to captured images, Proofig AI analyzes graphs, charts, diagrams, and plots.
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How does Proofig handle images with intentional duplications (e.g., replicate experiments)?

Proofig flags all potential duplications without making final judgments. This approach is crucial because intentional duplications, like replicate experiments, are a legitimate part of scientific research. We provide advanced investigation tools to help users examine flagged images in detail, including color maps, histogram equalization, and contrast and brightness filters. Users have the final decision on which issues to include in the report, ensuring that intentional and valid duplications are not misclassified as integrity issues.
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How does Proofig stay updated with new AI image generation techniques?

Proofig continuously monitors advancements in AI image generation. Like an immune system adapting to new threats, we're committed to expanding our capabilities to protect scientific integrity. We strive to enhance our detection algorithms as new AI models emerge in the field.

What is Source Inspector?

Source Inspector reads what an original image file carries with it: its Content Credentials and the metadata written by the camera, microscope or software. Drop in one file, a set or a folder; it reports on each file and, from four files up, compares them and points out what stands out. With two or three it says there are too few to establish a baseline and asks you to review each one on its own. Every file is analysed inside your browser, so nothing is uploaded. Open it from Source inspect in the left menu.


3. Using Proofig

Who can use Proofig's services?

Proofig supports:

Whether you're preparing to publish, submit a grant, file a patent, or review published work, Proofig ensures image integrity.
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How can I use the Proofig system?

Using Proofig is simple:

  1. Log in to your Proofig account.

  2. Upload your manuscript or images (PDF or image files).

  3. Our AI system automatically analyzes the images.

  4. Review the results and any flagged issues.

  5. Generate a comprehensive report with one click.

The entire process is automated and typically takes just a few minutes. Our platform includes intuitive guides to assist you at every step.
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Can I start from LabArchives?

Yes. On the Proofig AI sign-up page, click Sign up with LabArchives to get instant access with your LabArchives account. Choose your region (Rest of the world or Australia) so Proofig AI connects to the right LabArchives server, then connect your notebook and select the notebook page you want to analyze. Proofig AI analyzes the images, highlights suspected issues, and lets you review findings and generate a report. Note that PDF upload is not available through the free LabArchives flow.

How do I understand what Proofig found?

The Review Assistant is a side panel that explains each finding: what was found, what it means, its severity, the signal behind the finding, and recommended follow-up actions, tailored to your user type. A short "What do I see?" explanation is also shown inline within the report itself. See Understanding Your Findings.

What is a sub-image?

A sub-image is related to any single image, for example one microscopy picture or one line of western blot bands. Proofig is capable of analyzing a wide variety of images, including western blot bands, all types of microscopy slides (confocal, light or electron), plates, plants, mice, in-vitro and in-vivo images, graphs, charts, diagrams, and plots, and more.
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Do I need to submit all files manually?

Proofig supports both manual and automated uploads. You can also upload your manuscripts individually or by automated system using REST API, allowing an automated connection.
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Can I upload more than one manuscript at a time?

Yes. You can upload up to 8 manuscripts at once. Each manuscript is analyzed separately and produces its own report. Manuscripts are not compared against each other, so uploading several together does not check for duplication between them.

How much does it cost?

Proofig AI is sold in packages of submissions. One submission is one manuscript, sent for analysis as a single PDF or Word file, and while the launch offer runs every package covers both Proofig AI and Octym. Starter is $99 for 3 submissions, Growth $249 for 8, Pro $399 for 14 and Pro Plus $549 for 22, in US dollars and valid for 12 months from purchase. You buy from inside the app, on the Settings page. For the current list, see our pricing page. For a different volume or more users, contact us with your role, your needs and the number of manuscripts you expect to submit.

If you are on an older per-sub-image plan, it keeps working. See our pricing article for what happens when you move to submissions.

Can I share a report with someone who does not have an account?

Yes, once sharing has been switched on: by your administrator, or by you in Settings if yours is a single-user account. Open one of your own reports, click Share view-only in the header, and create an expiring link or send an email invitation, whichever your administrator has turned on. An expiring link can carry a password; an email invitation can ask the recipient to confirm their address with a code. You can revoke a share at any time.

Is there a free Octym review?

Every personal account gets one free review in Octym, the Publication — Manuscript Submission Check, with no credit card. The free review shows part of the findings, and the rest, along with Chat, the Explore pages and PDF export, open up when you buy submissions. Buying also unlocks that first review in full, so a package of three submissions gives you four reviews.

Can I leave graphs out of an analysis?

The Submit page has an option, Exclude graphs, charts, diagrams and plots from this analysis. On a single-user account it is always available; on a multi-user licence an administrator switches it on. Panels you mark by hand are always analysed, and the choice is recorded in your report. It applies to every manuscript in that upload and cannot be changed after submission.


4. Technical Specifications

What type of files does Proofig support?

We analyze your entire article via a single PDF or Word (.doc / .docx) file, up to 50MB, with less than 100 pages. Word files are uploaded the same way as PDFs. Just upload your manuscript – and Proofig will do all the hard work for you.
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Can I upload images to Proofig?

Yes, you can upload images. Proofig automatically converts them into a PDF for analysis. Ensure the total size is under 50MB and within 100 pages. Supported image formats include JPEG, PNG, and TIFF. TIFF images can be uploaded both via Upload Images and through the LabArchives flow.

What are the system requirements?

Proofig supports Chrome browser. Firefox, Safari, and IE are currently not supported.

Do I need high-quality sub-images?

There is no need for high-resolution images. The PDF quality is checked on a 300DPI resolution.
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What do I need to download to work with Proofig?

Nothing – the Proofig system is available to use online. You can log in from any computer to upload your images or view your report. You can also print your final report or save it as a PDF.

How many sub-images can one manuscript contain?

A single manuscript can contain up to 750 sub-images. This is a per-manuscript limit on how many images we analyze in one document, and it can be raised for enterprise and B2B customers — contact us if you need a higher limit.

Can I use the app in dark mode?

Yes. The appearance control in the header, a sun or a moon rather than a word, offers Light, Dark and System, which follows your computer. The choice is kept in the browser you made it in, so you set it once per browser. Figures are never recoloured, and printing always uses the light palette.


5. Privacy and Security

Does Proofig use users' data to train their system and algorithms?

No, Proofig never uses data from user-uploaded manuscripts to train our models. We train our system exclusively using already published material within legal constraints. User-uploaded data is analyzed solely to detect image integrity issues in the submitted manuscript.
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How does Proofig ensure the confidentiality of my data?

All analyses are conducted on private, secure servers. Your manuscripts and reports remain fully confidential and are not used for any other purposes. We adhere to strict data privacy and security protocols to protect your data.
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Who sees my images and my results?

Proofig's system uses a private server for you to log in and upload your file. You receive your results confidentially and privately.


6. Comparison and Efficiency

Why is it essential to pre-check the figures in an article?

Pre-checking figures is crucial because:

  • Journals only publish a fraction of the articles submitted by researchers. Ensuring image integrity could increase your chances of publication.

  • Even honest mistakes can lead to image integrity issues. Studies indicate that about 25% of all life science articles published may contain inappropriate image manipulations, duplications, or other integrity problems, most unintentionally.

  • An estimated 35,000 articles published between 2009 to 2016 might be prone to post-publication retraction due to faulty figures.

  • Proofig's advanced AI technology detects various forms of image manipulation, duplication, AI-generated images, and other integrity issues, helping you avoid costly retractions and protect your reputation.

How does Proofig compare to manual image checking in terms of accuracy and time efficiency?

Proofig offers higher accuracy and significant time savings compared to manual checking. Our AI consistently applies rigorous standards, detecting subtle manipulations that might be missed by the human eye. The system can analyze an entire manuscript in minutes, dramatically reducing the time required for thorough image integrity checks.

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